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Acute monoblastic leukemia

MedGen UID:
141597
•Concept ID:
C0457334
•
Neoplastic Process
Synonyms: Acute Monoblastic Leukemia; Acute Monoblastic Leukemia (FAB M5a); FAB M5A; FAB type M5a; French-American-British type M5a
SNOMED CT: French-American-British type M5a (278170009); FAB M5A (22331004); FAB type M5a (278170009)

Definition

An acute myeloid leukemia in which the monoblasts represent 80% or more of the total cellular population. (WHO, 2001) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Acute monoblastic leukemia

Professional guidelines

PubMed

Biologic characteristics and treatment of acute nonlymphocytic leukemia in children. Report of the ANLL Strategy Group of the Childrens Cancer Study Group.
Lampkin BC, Lange B, Bernstein I, Woods W, Odom L, Wells R, Ruymann F, Feig S, Miller L, Chard R
Pediatr Clin North Am 1988 Aug;35(4):743-64. doi: 10.1016/s0031-3955(16)36508-7. PMID: 3047652
Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009
Acute monoblastic leukemia: diagnosis and treatment of ten cases.
McKenna RW, Bloomfield CD, Dick F, Nesbit ME, Brunning RD
Blood 1975 Oct;46(4):481-94. PMID: 169929

Recent clinical studies

Etiology

Hemophagocytic syndrome in children with acute monoblastic leukemia-another cause of fever of unknown origin.
Lackner H, Seidel MG, Strenger V, Sovinz P, Schwinger W, Benesch M, Sperl D, Urban C
Support Care Cancer 2013 Dec;21(12):3519-23. Epub 2013 Aug 24 doi: 10.1007/s00520-013-1937-x. PMID: 23975227
The role of chemotherapy in pediatric clival chordomas.
Dhall G, Traverso M, Finlay JL, Shane L, Gonzalez-Gomez I, Jubran R
J Neurooncol 2011 Jul;103(3):657-62. Epub 2010 Nov 5 doi: 10.1007/s11060-010-0441-0. PMID: 21052774
Teniposide in lymphomas and leukemias.
Sonneveld P
Semin Oncol 1992 Apr;19(2 Suppl 6):59-64. PMID: 1411640
Acute monoblastic leukemia: a unique subtype--a review from the Childrens Cancer Study Group.
Odom LF, Lampkin BC, Tannous R, Buckley JD, Hammond GD
Leuk Res 1990;14(1):1-10. doi: 10.1016/0145-2126(90)90140-5. PMID: 2406511
Acute monoblastic leukemia: a clinical and biologic study of 74 cases.
Tobelem G, Jacquillat C, Chastang C, Auclerc MF, Lechevallier T, Weil M, Daniel MT, Flandrin G, Harrousseau JL, Schaison G, Boiron M, Bernard J
Blood 1980 Jan;55(1):71-6. PMID: 6927957

Diagnosis

Leukemia cutis - A case of cutaneous manifestation of acute monoblastic leukemia.
Mandal AP, Das R, Sengupta M, Chatterjee U
J Cancer Res Ther 2023 Apr-Jun;19(3):826-828. doi: 10.4103/jcrt.jcrt_350_21. PMID: 37470620
Acute monoblastic myeloid leukemic pleural effusion: Pitfalls and clues.
AbdullGaffar B, Farhan R, Dutta P
Diagn Cytopathol 2023 Feb;51(2):E59-E64. Epub 2022 Oct 29 doi: 10.1002/dc.25068. PMID: 36308418
Acute monoblastic leukemia with t(8;16): a distinct clinicopathologic entity; report of a case and review of the literature.
Sun T, Wu E
Am J Hematol 2001 Mar;66(3):207-12. doi: 10.1002/1096-8652(200103)66:3<207::aid-ajh1046>3.0.co;2-q. PMID: 11279628
Neuroblastoma presenting as acute monoblastic leukemia.
Boyd JE, Parmley RT, Langevin AM, Saldívar VA
J Pediatr Hematol Oncol 1996 May;18(2):206-12. doi: 10.1097/00043426-199605000-00024. PMID: 8846141
Acute monoblastic leukemia: a unique subtype--a review from the Childrens Cancer Study Group.
Odom LF, Lampkin BC, Tannous R, Buckley JD, Hammond GD
Leuk Res 1990;14(1):1-10. doi: 10.1016/0145-2126(90)90140-5. PMID: 2406511

Therapy

Acute monoblastic leukemia presenting with striking periorbital and periauricular infiltration.
Brierley CK, Eyre TA
Blood 2017 Jun 22;129(25):3396. doi: 10.1182/blood-2017-03-765776. PMID: 28642361
Simultaneous presentation of acute monoblastic leukemia and mantle cell lymphoma: case report and review of the literature.
Pawarode A, Baer MR, Padmanabhan S, Wallace PK, Barcos M, Sait SN, Block AW, Wetzler M, Battiwalla M
Leuk Lymphoma 2005 Dec;46(12):1813-8. doi: 10.1080/10428190500244258. PMID: 16263586
Hematologic and molecular spontaneous remission following sepsis in acute monoblastic leukemia with translocation (9;11): a case report and review of the literature.
Müller CI, Trepel M, Kunzmann R, Lais A, Engelhardt R, Lübbert M
Eur J Haematol 2004 Jul;73(1):62-6. doi: 10.1111/j.1600-0609.2004.00248.x. PMID: 15182340
Acute monoblastic leukemia: a unique subtype--a review from the Childrens Cancer Study Group.
Odom LF, Lampkin BC, Tannous R, Buckley JD, Hammond GD
Leuk Res 1990;14(1):1-10. doi: 10.1016/0145-2126(90)90140-5. PMID: 2406511
Acute monoblastic leukemia: diagnosis and treatment of ten cases.
McKenna RW, Bloomfield CD, Dick F, Nesbit ME, Brunning RD
Blood 1975 Oct;46(4):481-94. PMID: 169929

Prognosis

CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition.
Galland A, Gourain V, Habbas K, Güler Y, Martin E, Ebel C, Tavian M, Vallat L, Chenard MP, Mauvieux L, Freund JN, Duluc I, Domon-Dell C
Mol Oncol 2021 Sep;15(9):2318-2329. Epub 2021 Jun 26 doi: 10.1002/1878-0261.12982. PMID: 33960108Free PMC Article
Bone Marrow Necrosis in Acute Monoblastic Leukemia.
Terao T, Matsue K
N Engl J Med 2021 Feb 18;384(7):650. doi: 10.1056/NEJMicm2026508. PMID: 33596359
Hemophagocytic syndrome in children with acute monoblastic leukemia-another cause of fever of unknown origin.
Lackner H, Seidel MG, Strenger V, Sovinz P, Schwinger W, Benesch M, Sperl D, Urban C
Support Care Cancer 2013 Dec;21(12):3519-23. Epub 2013 Aug 24 doi: 10.1007/s00520-013-1937-x. PMID: 23975227
Acute monoblastic leukemia with t(8;16): a distinct clinicopathologic entity; report of a case and review of the literature.
Sun T, Wu E
Am J Hematol 2001 Mar;66(3):207-12. doi: 10.1002/1096-8652(200103)66:3<207::aid-ajh1046>3.0.co;2-q. PMID: 11279628
Acute monoblastic leukemia: a clinical and biologic study of 74 cases.
Tobelem G, Jacquillat C, Chastang C, Auclerc MF, Lechevallier T, Weil M, Daniel MT, Flandrin G, Harrousseau JL, Schaison G, Boiron M, Bernard J
Blood 1980 Jan;55(1):71-6. PMID: 6927957

Clinical prediction guides

A rare KMT2A::CBL transcript in an acute monoblastic leukemia patient with an unfavorable outcome.
Yu J, Song F, Zhang M, Xiao P, Feng J, Hong R, Hu Y, Huang H, Wei G
Mol Biol Rep 2024 Apr 21;51(1):561. doi: 10.1007/s11033-024-09543-0. PMID: 38643442Free PMC Article
Clonal dynamics in a case of acute monoblastic leukemia that later developed myeloproliferative neoplasm.
Sato S, Itonaga H, Taguchi M, Sawayama Y, Imanishi D, Tsushima H, Hata T, Moriuchi Y, Mishima H, Kinoshita A, Yoshiura KI, Miyazaki Y
Int J Hematol 2018 Aug;108(2):213-217. Epub 2018 Feb 7 doi: 10.1007/s12185-018-2419-1. PMID: 29417354
mRNA expression profiling of histone modifying enzymes in pediatric acute monoblastic leukemia.
Xiao PF, Tao YF, Hu SY, Cao L, Lu J, Wang J, Feng X, Pan J, Chai YH
Pharmazie 2017 Mar 1;72(3):177-186. doi: 10.1691/ph.2017.6768. PMID: 29442054
Hemophagocytic syndrome in children with acute monoblastic leukemia-another cause of fever of unknown origin.
Lackner H, Seidel MG, Strenger V, Sovinz P, Schwinger W, Benesch M, Sperl D, Urban C
Support Care Cancer 2013 Dec;21(12):3519-23. Epub 2013 Aug 24 doi: 10.1007/s00520-013-1937-x. PMID: 23975227
Chromosome clues to acute leukemia in Down's syndrome.
Hecht F, Hecht BK, Morgan R, Sandberg AA, Link MP
Cancer Genet Cytogenet 1986 Mar 15;21(2):93-8. doi: 10.1016/0165-4608(86)90034-8. PMID: 2936445

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